SNX17 Antibody, HRP conjugated

1. HPV-16 L2 recruitment of SNX17 occurs prior to capsid disassembly. PMID: 28475030
2. The double knockdown of SNX17 and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein. PMID: 26202251
3. SNX17 plays a role in the maintenance of normal surface levels of activating receptors and integrins to permit optimum T cell activation at the immune synapse. PMID: 25825439
4. Data indicate that the major binding site for binding of sorting nexin 17 (SNX17) is confined to the NPXF2 motif in cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1). PMID: 25059659
5. Sorting nexin 17 regulates ApoER2 recycling and reelin signaling. PMID: 24705369
6. The authors demonstrate that SNX17 is essential for infection with all papillomavirus types analyzed, indicating an evolutionarily highly conserved virus entry mechanism. PMID: 23115288
7. depletion of SNX17 in HeLa cells resulted in lysosomal degradation of multiple members of the integrin family of extracellular matrix recep-tors. PMID: 22492727
8. expression level of SNX17 may regulate the lysosomal degradation, at least for P-selectin, by suppressing its entry into the inner vesicles of the multi-vesicular bodies (MVBs) PMID: 15769472
9. Snx 17 binds to a motif in the low-density lipoprotein (LDL) receptor-related protein (LRP) tail distinct from the endocytosis signals and promotes LRP sorting to the recycling pathway in the early endosomes. PMID: 16052210
10. SNX17 has a role in the indicated KRIT1 function in cell adhesion processes by integrin signaling PMID: 16712798
11. SNX17 regulates amyloid precursor protein trafficking and processing in the early endosomes PMID: 18276590

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HGNC: 14979

OMIM: 605963

KEGG: hsa:9784

STRING: 9606.ENSP00000233575

UniGene: Hs.278569